I just finished it, logged in about 46 hours. I didn't do all the side quests, but I did enough.
This is one of the best RPGs I ever payed. It even improved on Mass Effect though I wish it did a few things that ME did.
My few gripes are eclipsed by the epic scale, visuals, story, memorable characters... The list goes on and on.
This has to be the RPG of the year.
IMO Bioware is #1 in RPGs now. Period.
I'm sure ME2 will build on a lot of things and the engines are similar.
I am thinking of not trading this in and holding onto it. I usually dont replay RPGs again, but this will be worth it.
Now I can't wait for ME2 in January.