First, where he struggles. NFL has taken away our All-22, ********.
This is his first week back from the injury against the Patriots, week 6. Denver has a bunch flood-type route combo here with motion to the trips. The tight end runs a hitch, the outside wide receiver (Patrick, I believe) runs a go option corner and the crossing wide receiver (Hamilton, maybe?) runs an arrow. Jeudy is on the other side of the field making a fool of the backside Patriot corner.
The Patriots are in a Cover-1, but the man-to-man is disguised into what's probably a hybrid man concept on the bunch formation with the second safety blitzing. The nickel, or dime, which ever he is that follows Hamilton(?) across the line is the guy who mans Patrick deep while the safety is playing the deep high. The left side linebacker plays man-up with the tight end, the right linebacker plays the flat, as does the outside corner down to the bottom (the left corner).
Lock sees the deep safety, but never looks off Patrick. He plays it the whole way.
Jeudy, meanwhile on that backside cross has made an absolute fool of the backside corner. Lock had successfully looked off the single high safety, but just didn't look back across the formation, instead he threw into double coverage.