I'd like to see some of the darker graphic novel franchises get some love. I really liked Y:Last Man & Saga--both by Brian Vaughn. There are a ton of quality titles that could spice up what we get--but they wouldn't have the same popcorn draw as an Avengers. More toward the Punisher and Logan side of things.
How about Preacher, the Ennis comic?
As far as books go, what about the Steven Erikson series? That *has* to happen. I wonder if anyone has the movie rights and is planning something.