I know everyone has fallen in love with the running game this week, and especially after the poor rushing performance at St. Louis, but I think Denver needs to utterly reverse strategy against Kansas City.
Kansas City's offense is built to get a lead and maintain it, not to come from behind. I think Denver needs to come out firing in three- and four-wide sets and blitz the Kansas City defense through the air to try to get an early lead. Denver needs to set a completely different tone against Kansas City. One that has worked the past few years against the Chiefs defense too. I have confidence in Manning's and the offensive line's ability to not allow Houston and Hali to get to Manning that I think this strategy would be the best way to handle this game.
Sure, keep the running game in mind, and even run the six offensive line set later in the game, when you have a lead. Early, Denver should come out firing.